The study finds no association between vaccination against HPV and increased risk of blood clot

The study finds no association between vaccination against HPV and increased risk of blood clot -

Although some data have suggested a potential association between receiving the quadrivalent human papillomavirus (HPV) and venous thromboembolism subsequent vaccination (VTE; blood clot), an analysis that included more than 500,000 women who received the vaccine did not find an increased risk of VTE, study says published in the July issue 9 JAMA [

"security problems can undermine immunization programs at the expense of public health, and timely assessments of these concerns are essential "the authors write.

Nikolai Madrid Scheller, MB, of the Statens Serum Institut, Copenhagen, Denmark, and colleagues used data from Danish national registries to assess the potential link between HPV vaccination quadrivalent and VTE. Information on vaccination, use of oral contraceptives, use of anticoagulants (blood thinners), and the result of a first diagnosis of VTE in the hospital are not related to pregnancy, surgery, or cancer was obtained from the Danish registers.

The study included all Danish women, aged 10 to 44 years, from October 06 to July 2013 (n = 1,613,798), of which 500,345 (31 percent) who received the quadrivalent vaccine against HPV ; there were 4,375 incident cases of VTE. Of these, 889 women (20 percent) were vaccinated during the study period. Data analysis did not find an association between the quadrivalent vaccine against HPV and VTE during the 42 days after vaccination (defined as the main risk period).

"Our findings, which were consistent after adjusting for the use of oral contraceptives and among girls and young women, and women mid-adult, do not provide support to an increased risk of VTE after the quadrivalent HPV vaccination, "the researchers write.