Wednesday, May 14, 2014

sugar-coated cells are potentially fatal to patients with cancer

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sugar-coated cells are potentially fatal to patients with cancer -

from the face of every living cell has a built-protein membrane is covered in chains polysaccharides - a literal sugar layer. A new study led by a researcher from Cornell University found that coating is especially thick and pronounced on cancer cells and is a key determinant of the survival cell. Compound of decorated sugar molecules long called glycoproteins, the coating causes physical changes in the cell membrane that make better able to thrive cell -. Leading to a deadly cancer

Matthew Paszek, assistant professor of chemical and biomolecular engineering at Cornell and Valerie Weaver of the University of California, San Francisco, conducted the study on the survival of cancer cells induced glycoprotein, published online in Nature .

researchers found that long chain glycoproteins on the surface of a cancer cell causes the cell membrane to push away from its environment and bend inward. This physical change causes adhesion receptors on the cell surface integrins known to be agglomerated. Integrins bind to scaffolding proteins in their environment and regulate almost everything a cell does -. Movement, change and growth

This grouping mechanism causes integrins alter the normal signaling of the cell, leading to uncontrolled growth and survival [

"changes to the composition sugar on the cell surface might physically modify how receptors are organized, "he said." it's really the great thing :. Coupler regulating the sugar coating to these biochemical signaling molecules "

the document, "the glycocalyx mechanically initiates cancer growth and survival of integrin-mediated," was the subject of a "News and views" feature in nature.


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