Diabetes linked to increased risk head and neck -
By Laura Cowen, medwireNews Reporter
risk People with diabetes mellitus have a significant increase in the development of head and neck cancer (HNC) compared to those without the condition, show the results of a large study conducted in Taiwan.
Yung-Song Lin (Taipei Medical University) and colleagues have shown that the incidence of CST was 1.47 times higher in a cohort of over 89,000 patients with diabetes than it was in a size equal control group matched for age, sex, geographic location, income and comorbidities, including obesity, coronary heart disease, hyperlipidemia, hypertension, chronic kidney disease and chronic obstructive pulmonary disease (used as a substitute for smoking).
These findings "underscore the importance of monitoring patients with [diabetes mellitus] to CST," the researchers note.
This may be particularly true for men and patients aged 40-65 years, as the incidence was highest in these groups.
among the specific evaluated CST, cancer of the oral cavity had the highest incidence in both groups but was significantly more common in patients with diabetes (0.41%) than controls (0.24%) during the follow-up period, which began in 02 and continued until the death of the participant or at the end of 2011, whichever comes first.
oropharyngeal cancer and nasopharyngeal carcinoma were also significantly more frequent in the diabetes group.
After adjusting for age, sex, comorbidity, patients with diabetes had once 1.48 increased risk of CST compared to controls. The risk was 1.74 times higher for the oral cavity cancer, 1.53 times higher for cancer of the oropharynx and 1.40 times higher for nasopharyngeal carcinoma. No increased risk was observed for cancers of the hypopharynx, or larynx rhinosinusitis.
Note, the researchers observed no significant difference in overall survival between the diabetes and control groups that developed CST, but they suggest that this may be because the follow -up periods have been limited by the reduced overall survival observed in participants who developed CST.
Writing in JAMA Otolaryngology-Head and Neck Surgery , Lin and his team say that the mechanisms underlying the association between diabetes and the development of HNC remain unclear.
They suggest that long-term exposure to insulin may be a factor as "[i] nsulin is a powerful growth factor that promotes proliferation and carcinogenesis in various ways, directly. and through [insulin-like growth factors] "
They add:" Another reasonable explanation is hyperglycemia, which can promote tumors directly :. cancer cells based on increased consumption of glucose "
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