Risk of urinary tract infection after biopsy of the highest prostate in men with previous infections

Risk of urinary tract infection after biopsy of the highest prostate in men with previous infections -

risk of urinary tract infections after prostate biopsy the higher in men with previous infections or significant comorbidities, Swedish researchers report in T he Journal of Urology ^®

ultrasound TRUS-guided biopsy is the gold standard for detecting prostate cancer, but international reports have suggested that the number of risks associated with the procedure increases. In a new study based on the population nationwide, Swedish researchers found that six percent of men filled a prescription for antibiotics for a urinary tract infection within 30 days after having a prostate biopsy, with a double increase in hospital admissions over five years, reports the Journal of Urology®.

previous studies reported serious side effects after prostate biopsy, including infection of febrile urinary tract and urosepsis in one to four percent of men, despite the use prophylactic antibiotics. There have also been reports that chronic diseases such as diabetes, benign prostatic hyperplasia (BPH), and a history of urinary tract infection increases the risk of infections.

To estimate the incidence of infection after prostate biopsy and evaluate infection risk factors and mortality at 0 days in Sweden, researchers examined more than 51,000 men enrolled in folders Swedish prostate cancer database who underwent transrectal ultrasound guided prostate biopsy between 06 and 2011. They also compiled the data from the National Register of prostate cancer (NPCR) of Sweden, which captures more 96 percent of all newly diagnosed cancers of the prostate in the country.

"We sought to estimate the frequency and severity of infectious complications in men diagnosed with prostate cancer after prostate biopsy by examining how many men prescriptions of antibiotics related to tract infections urinary, hospitalization rates within 30 days, and death due to infection filled, "says lead investigator Karl-Johan Lundström, MD, Department of surgery and perioperative Sciences, Urology, Andrology, Umeå University , Ostersund, Sweden. "We also capitalized on the unique databases at national health care crosslinked scale in Sweden to make a more comprehensive assessment of potential risk factors for infectious complications," he added.

Among men who filled a prescription for antibiotics urinary tract within 30 days of biopsy, 54 percent completed the requirement in the first week after the biopsy. One percent of men were hospitalized with a urinary tract infection.

Between 06 and 2011, the number of men getting a prescription for antibiotics after the biopsy has declined, while the number who were hospitalized increased. Was observed no significant increase in mortality of 0 days, however.

The most risk of antibiotic prescribing factors were multiple comorbidities, especially diabetes, and prior infection. Overall, about two percent of the men had a urinary tract infection in the six months preceding the biopsy.

"Our data show that severe infections requiring hospitalization after prostate biopsy increases in Sweden. The rate of admission to hospital has increased twofold during this five-year period. However, the risk to die of infection after prostate biopsy is very small, "observed Dr Lundström. "The risk of post-biopsy infection is highest among men with a history of urinary tract infections and those with significant comorbidities. The increased risk of hospitalization is concerning and highlights the importance of 'carefully assess indications for biopsy particularly in men at increased risk of infection, "he concludes.