proton beam therapy improves cancers of the head and neck free survival compared to IMRT -
A new study by radiation oncologists at Mayo Clinic comparing world literature on the results of proton beam therapy in the treatment of a variety of advanced head and neck cancers of the base of skull relative intensity modulated radiotherapy (IMRT) found that proton beam treatment significantly improved disease-free survival and tumor control relative to IMRT. The findings appear in the journal Lancet Oncology .
"We undertook a systematic review and meta-analysis to compare clinical outcomes of patients treated with proton therapy with patients receiving IMRT photon," says lead author Robert Foote, MD, a radiation oncologist at the Mayo Clinic. "Our results suggest that the theoretical benefits of proton therapy beam may actually be real."
the researchers examined studies of the nasal cavity and tumors of the paranasal sinuses . through vast databases of research They included studies of patients who had no treatment - or primary radiation therapy or adjuvant radiotherapy. - and patients who have had recurrent disease researchers collected data on overall survival, disease-free survival, and tumor control in five years and longer patient follow-up. They used random effects models to pool results across studies and compared the event rates combined results for proton and IMRT therapy using a test for interaction.
The researchers found disease-free survival significantly higher at five years for patients receiving proton therapy for patients receiving IMRT (72% against 50%). Tumor control did not differ between the five treatment groups but the control of the tumor was higher in patients receiving proton IMRT for the longest follow-up (81% against 64%).
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