The research sheds new light on the complicated brain barrier fabrics -
Research from the University of Copenhagen, sheds new light on the complicated barrier of brain tissue . The blood-brain barrier is an effective barrier that protects the brain, but at the same time, it is hard to treat diseases such as Alzheimer's disease. In a barrier in vitro blood-brain, researchers can recreate the brain of the transport process for development of new drugs to the brain. New research results are published in AAPS Journal .
Ninety-five percent of all pharmacological agents tested for the treatment of brain disorders fail because they can not cross the blood-brain barrier. It is therefore important to find a possible method to transport drugs past outpost effective brain and fervent protector.
Researchers from the Pharmacy Department of the University of Copenhagen have recreated the complex blood-brain barrier in a laboratory model that is based on cells from animals. In a new study, the researchers studied the protein rowdy bouncer into the fabric of the fence. Proteins protect the brain, but also prevent the treatment of brain diseases:
"The blood-brain barrier is chemically tight because the cells contain transport proteins that ensure that the substances used in the cells are thrown directly back into the bloodstream again, we have shown that the barrier that we have created in the laboratory contains the same protein bouncer -.. and they behave the same way as in a "real" brain This is important because the model can be used to test drive the hard way in the complex brain phenomena -. we have so far only been able to study live animals -can now be studied in experiments simple laboratory using cultured cells, "says postdoc Hans Christian Cederberg Helms of pharmacy Department.
The research team showed that the P-glycoprotein transporter proteins, breast cancer resistance protein and multidrug resistance-associated protein 1 are active in the tissue barrier created artificially. Pharmacological agents pump proteins of the "brain side" to the "blood side" in the same manner as the human blood-brain barrier.
Collaboration finds a way
new findings resulted from the collaboration with industrial scientists at the pharmaceutical company H. Lundbeck A / S
"It is important for the treatment of brain diseases such as Alzheimer's disease that we find a way around the effective defense of the brain. university and industry must work together to overcome the fundamental challenges inherent in developing pharmaceutical products for the future, "says Lassina Badolo, senior scientist with H. Lundbeck a / S and an expert on drug absorption into the body
associate Professor Birger Brodin added.
"We have shown that the models have the same bouncer protein than those found in the intact barrier We are studying proteins. the blood-brain barrier that accept pharmacological agents instead of throwing them away. If we can combine a beneficial substance that the brain needs a so-called "protein absorber," we will in the long run be able to pass pharmacological agents across the blood-brain barrier. "
Birger Brodin heads the group Drug Transporters in ADME research, which is responsible for the blood-brain barrier in vitro.
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