The researchers attributed $ 3.3 million NIH grant to study the role of genetics in protecting against fragility -
The brittleness is a common condition associated with old age, characterized by weight loss, weakness, decreased activity level and reduced mobility, thereby increasing the risk of injury and death. Yet all seniors become brittle; some remain vigorous and robust well into old age. The question remains: why
the Albert Einstein College of Medicine Researchers at Yeshiva University have received a grant of $ 3.3 million from the National Institutes of Health (NIH) to study the role of genetics in protecting against fragility. The study will be conducted by Nir Barzilai, MD, director of the Institute for Research on Aging and Leon Rennert Chair Ingeborg and Ira in aging research at Einstein and attending physician, medicine at Montefiore Medical Center, and Joe Verghese, MBBS, D Murray. Gross Memorial Faculty Scholar in Gerontology at Einstein, chief of geriatrics at Einstein and Montefiore Einstein Center and director of the Montefiore for brain aging.
"people who are frail are more vulnerable to serious complications due to falls or surgery and more susceptible to infection," said Dr. Verghese. "Understanding why some elderly suffer loss balance or strength, and do not suffer from abnormal gait can help us to prevent and treat such a physical decline. "
The new project draws on the resources LonGenity research Einstein study, which is based on the longevity genes Project, an ongoing study of 15 with more than 500 Ashkenazi Jews over the age 95. LonGenity compares the genetics of centenarians and their children with those with the usual survival. Over the past 10 years, the team of Dr. Barzilai has identified several biomarkers that can explain their extreme longevity.
"We found that our centenarian participants have a significant genetic advantage over the general population. Their rare genetic variants helped to live longer, healthier and prevent or significantly delay related diseases age, such as Alzheimer's disease and type 2 diabetes, "said Dr. Barzilai,." We want to know whether a family history of these "longevity genes" reduces the risk of fragility. "
the researchers will build a pilot study funded by the American Federation for aging research that links the exceptional longevity to improve physical function and reduced risk of fragility. the Einstein team plans to continue these early efforts to identify genetic variants that prevent frailty in the bay, explore the biological pathways that can lead to fragility and develop drugs that mimic the effect of the prevention of fragility genes.
Five -Year grant, "Role of exceptional longevity genotypes in protecting against fragility in aging" (R01AG044829), was awarded by the National Institute on Aging, part of the NIH.
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