Researchers at Yale University identified the bacterial culprits that lead ITN -
Yale University researchers have identified a handful of bacterial culprits that can lead inflammatory diseases of the intestine (IBD) such as Crohn's disease and ulcerative colitis, using the own intestinal immune responses of patients as a guide.
results are published Aug. 28 in the journal cell .
trillions of bacteria exist in the human intestinal microbiota, which plays a crucial role in the development and progression of IBD. However, he thought that only a small number of bacterial species affect the susceptibility of a person to the EIA and its potential severity.
"A handful of bad bacteria are able to achieve access to the immune system and get right in the gut," said Richard Flavell, Sterling Professor of Immunobiology at Yale School of Medicine. "If you look at the bacteria we did an immune response, you can begin to find these bad actors."
Flavell research team focused on antibodies coatings on the surface of bacteria. In particular, Yale researchers examined bacteria with high levels of an antibody called immunoglobulin coating A (IgA).
"The coating is the attempt of the body to neutralize the bacteria," said Flavell. "It binds to bad bacteria. We make these IgA responses to a limited number of organizations. "
He and his team have confirmed a correlation between high levels of IgA coating and inflammatory responses in the human gut. To do this the team collected the "good" and "bad" bacteria from a small group of patients and transplant them into mice. in healthy mice, there was no influence on the intestinal inflammation. in mice with induced colitis, those with the bacteria suspected of "bad" showed signs of excessive inflammation and other symptoms of IBD
Flavell warned that more research is necessary to learn how many bacterial species are classified "bad" and if these populations are common to all patients with IBD or are unique to each patient.
But the study results indicate that the anti-bacterial therapies for IBD are possible, Flavell said. Such anti-bacterial approaches may include very specific antibiotics, vaccines and probiotics.
"We believe an antibacterial strategy has a place in the treatment of IBD," said Flavell.
EmoticonEmoticon