Recurrence of breast cancer cut by ½ in overweight women who regularly used NSAIDs

Recurrence of breast cancer cut by ½ in overweight women who regularly used NSAIDs -

aspirin recurrence of breast cancer related to hormone was reduced half of women overweight and obese people who regularly used or other nonsteroidal anti-inflammatory drugs (NSAIDs), according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"Our studies suggest that limiting the inflammatory signaling may be an effective, less toxic approach to change the effects favoring obesity cancer and improving the patient's response to hormone therapy "said Linda A. deGraffenried, PhD, associate professor of nutritional sciences at the University of Texas at Austin.

The study found that women with a body mass index (BMI) greater than 30 and had estrogen receptor alpha (ERa) the -positive breast cancer had a rate of 52 percent less recurrence and a 28-month delay in time to relapse if they took aspirin or other NSAIDs.

"These results suggest that NSAIDs may enhance the response to hormonal treatment, allowing more women to remain on hormone therapy rather than having to change to chemotherapy and to treat complications and associated side effects" , deGraffenried said. "However, these results are preliminary and patients should never start treatment without consulting their doctor."

experiments using blood of obese patients, deGraffenried and colleagues conducted in the laboratory to recreate an environment containing tumor cancer cells, fat cells and immune cells that promote inflammation. They found that the factors associated with obesity initiate a signaling network within the tumor environment to promote the growth and resistance to therapy.

"These studies show that the benefit of aspirin [and other NSAIDs] will be in those with a disease caused by inflammation, not only obesity," said DeGraffenried.

researchers used data from 440 women diagnosed with invasive breast cancer, ER positive and treated at the University of Texas Health Science Center and the Center for Clinical Cancer START, both in San Antonio Texas between 1987 and 2011.

of the women studied, 58.5 percent were obese and 25.8 percent were overweight. About 81 percent took aspirin and the remainder took other NSAIDs. About 42 percent and 25 percent took statins and omega-3 fatty acids, respectively.

There was an indication of the protection of aspirin and other NSAIDs, even after controlling statins and omega-3 fatty acid utilization, which also have anti-effects inflammatory.