New analysis tool online process re-engineering cells for biomedical research reinforces -
A Mayo Clinic researcher and his collaborators have developed an analysis tool online that will accelerate and improve the process of re-engineering cells for biomedical research. CellNet is a platform Internet self-service that uses network biology methods to help stem cell engineering. Details Cellnet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell .
"This free platform has a wide range of uses for all types of surveys based on cells and can potentially provide assistance to those working on all types of cancer," said Hu Li , Ph.D., a researcher at the Mayo Clinic Center for individualized medicine and Department of experimental molecular pharmacology and therapeutics, and co principal investigator in both works. "CellNet show how an engineering cell resembles the actual consideration and even suggests ways to solve engineering. "
the network biology platform contains data on a wide range of cells and details on what is known about cell types. researchers say that the platform can be applied to almost any study and allows users to refine the engineering process. in the long term, it should provide a reliable shortcut to the early drug development phases, individualized cancer therapies and pharmacogenetics.
Cellnet uses 21 types of tissues and cells and data from 56 published studies in human genius and mouse as a basis for the analysis and prediction of cell fate and corresponding engineering strategies. Also the platform offers classification scores to determine differentiation and conversion of induced pluripotent stem cells. It reveals incomplete conversion microphagous and engineering hepatocytes. CellNet can be used to query the cell fate after expression profiling, classifying each type of cell entry, gene quantification state regulatory system, and identification of outliers regulators affecting the engineering process . All this is useful for predicting the success of transplantation of cancerous tumors in the mouse avatars for cancer research and drug development.
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