Study reveals link between common respiratory disease and an increased risk of lung cancer -
The links between a number of common respiratory disease and an increased risk of cancer of developing lung have been found in a large pooled analysis of seven studies involving more than 25,000 people.
"associations between various respiratory diseases and lung cancer has been shown in previous studies, but few of these studies considered simultaneously several respiratory diseases," said researcher Ann Olsson, PhD, of the international Agency for research on cancer in Lyon, France. "In our pooled analysis of seven case-control studies involving more than 12,500 cases and 14,00 controls, we found associations between lung cancer and chronic bronchitis, emphysema and pneumonia, with a greater risk of cancer lung increased in subjects with all three of these conditions. "
results were published in American Journal of the American Thoracic Society of Respiratory and Critical Care Medicine .
data on five previous respiratory diseases (chronic bronchitis, emphysema, tuberculosis, pneumonia and asthma) were collected through self-evaluation. the statistical analyzes were adjusted for study center, the age, employment in occupations with an excess risk of lung cancer, the level of education and detailed smoking habits.
pneumonia and chronic bronchitis were the previous respiratory diseases most frequently reported. In the setting of tests for other respiratory diseases and smoking, chronic bronchitis and emphysema were positively associated with lung cancer, with odds ratios of 1.33 among men (95% CI 1 20 to 1.48) for bronchitis and 1.50 (95% CI 1.21 to 1.87) for emphysema. A positive association was also found between pneumonia diagnosed two years or less before cancer and lung (OR = 3.31, CI 2.33 to 4.70 for men), asthma was an inverse association with risk of lung cancer, and no association was found between TB and lung cancer.
patients with concomitant chronic bronchitis, emphysema and pneumonia had a higher risk of lung cancer than those who have chronic bronchitis only. There was no association between chronic bronchitis and lung cancer in patients with co-occurring asthma or tuberculosis.
"Changes in the associations between lung cancer and models from previous respiratory diseases we observed in our study may indicate differences in etiologic mechanisms underlying" said Dr. Olsson. "A better understanding of these associations can help guide the type and frequency of clinical monitoring required for patients with each disease."
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