Review provides new knowledge about the diagnosis, treatment of PCOS

Review provides new knowledge about the diagnosis, treatment of PCOS -

The polycystic ovary syndrome (PCOS) affects more than 14 million women in the United States. The disorder increases the risk of endometrial cancer, heart disease, hypertension, type 2 diabetes, asthma, obesity, depression and anxiety, as well as infertility and a variety disorders of reproduction.

Despite its prevalence, no one has understood the origins of the syndrome or has developed early effective treatment strategies for it - until now. Thank you to some long-standing collaboration between researchers in Wisconsin, Illinois and California - and their students, who went on to become doctors better informed and researchers themselves -. The veil on the understanding and treatment of PCOS is finally lifted

A study published today in Current Pharmaceutical Design bundles decades of research and education in the overall progress to improve the lives of women with PCOS: a better orientation and managed care, new directions in genetic testing, the new diagnostic tests and the previous tests, such as measuring finger length ratios, and taking samples of hair strands hormones ripped the heads of newborn girls. Hunting diagnostic hormone does not stop there: the magazine tells 114 scientific and clinical articles that have transformed the PCOS biomarkers suspects in everything from head to coccyx

"With so many symptoms different, it took a long time. for doctors to identify the disease as most of infertility, "says David Abbott, professor of OB / GYN at the UW-Madison school of medicine and public health. the office and laboratory Abbott are the Wisconsin National Primate research Center, where he was addressing the problem of PCOS for nearly 30 years. he has hardly worked alone. His clinical colleagues longtime included Daniel Dumesic, professor, doctor and head of the Division of infertility and reproductive endocrinology at UCLA; Andrea Dunaif, professor of endocrinology and metabolism and physician at Northwestern University Feinberg School of Medicine, and Jon Levine which has already studied neuroendocrinology PCOS in rodents at Northwestern and is now director of the Wisconsin National Primate research Center, where he continues his active research program as well.

Toni Ziegler and Amita Kapoor, scientists with Assay Services Unit of the National Primate Research Center Wisconsin also recently completed the first study in the world showing that testosterone can be measured in newborn monkeys hair, to show if and when the monkeys were exposed to abnormal levels of testosterone as they develop in the uterus. "The test of the hair sample has the potential to become one of the pre-diagnostic tools for human infants believed to be at risk for PCOS because of genetic or other factors," says Abbott out. "A early diagnosis will help doctors focus on prepubescent interventions to improve PCOS appearance. "

in rodents to non-human primates to humans, these hormones hunters carried the revolutionary experiences that involve fetal origins of PCOS. They found that although PCOS symptoms do not appear until puberty, the disease can be programmed in the fetus during the second trimester of pregnancy. the following employees have revealed an even clearer picture of PCOS identifying the specific pathogenic genetic and epigenetic components shared between apes and women.

"Too many women are treated for diabetes, excess hair, obesity and other clinical presentations, but not the underlying problem, "Abbott said. "From other researchers, we now also know that PCOS is highly heritable, and potential candidate genes are emerging."

The monkey studies, in particular, involve the expression of the modified gene linked to a constellation of genes believed to play a role in PCOS, as well as in the storage of dysfunctional fats, sugar regulation in the blood by the pancreas, the brain and regulation of the menstrual cycle.

"This forward-thinking approach that the disease can be programmed in the fetus during intrauterine life promises to expand our understanding of how the maternal-fetal environment affects the health of women and their offspring in the next generation, "says Dumesic.

" Today, thanks to researchers and physicians working together on all aspects of this problem, many other clinicians refer to another, and catch several specific conditions that can lead to a diagnosis of PCOS and better care, "says Abbott.