ZMYND8 protein can suppress metastasis genes linked to cancer of the prostate -
Although it reads like the European license plate number, a protein known as the ZMYND8 name has demonstrated its ability to block metastasis-related genes in prostate cancer, according to research at the University of Texas MD Anderson cancer Center. The results from cell lines studies and mouse models, are published in the July 28 online issue of Molecular Cell.
"These results are important because cancer metastasis is a complicated process and is both devastating and clinically difficult," said Min Gyu Lee, Ph.D., associate professor of Molecular and Cellular Oncology . "For metastases, cancer cells acquire migratory and invasive abilities and gain new knowledge about how this happens and how to stop the metastasis is crucial. We believe that this study opens a window into the process."
Lee's study focused on modification of proteins essential for gene regulation, known as histones name. Modifications of histone modifications including acetylation and methylation, are frequently associated with the development of cancer. The Lee group ZMYND8 looked like a histone "reader" that could affect gene expression by recognizing these histone modifications called histone "marks".
"It has been well documented that the effects of histone acetylation and methylation of gene expression may be mediated by specific binding proteins known as" readers, "said Lee." We ZMYND8 identified as a player for histone H3K4me1 and brands called H3K14ac, both of which are associated with metastasis-related genes. "
the research group also noted that ZMYND8 cooperated with type histone mark "gum" known JARID1D to suppress metastasis related genes.
"These results are of particular interest in light of our earlier study that JARID1D levels are lower in prostate tumors metastasized than in normal prostate and primary prostate tumors, "said Lee. "This study revealed a metastasis suppressive previously unknown mechanism in which ZMYND8 counteracts the expression of genes related to metastasis by reading the marks and double histone H3K4me1 H3K14ac and cooperating with JARID1D".
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