OVC research may help improve the treatment of cancer -
Cancer treatment in people could be transformed through a study on the treatment of cancer in animals conducted by researchers at the Ontario Veterinary College (OVC) at the University of Guelph.
The results in mice and pets such as cats already lead to clinical trials to treat people with various forms of cancer.
researchers found that injection of oncolytic viruses (viruses that target cancer cells) intravenously in the spleen helps the immune responses to be stimulated much faster and at much higher amplitudes than traditional vaccination methods. Typically, physicians must wait weeks or months to administer a booster shot, in time to stop potentially fatal.
"Normally you have to wait until the immune response is down to administer the booster shot, but it means that serious and dangerous diseases, the answer would decline," said the professor of pathobiology Byram Bridle, lead author of the paper.
"You do not want to give any time the cancer to spread. What is the injection of virus in the spleen is that it allows us to bypass the regulatory mechanism that would limit its effectiveness. When we conducted these tests in animals, we saw the high success rate in the treatment of cancer. "
he said that the findings apply to many types of cancer, including breast cancer , leukemia, prostate cancer and osteosarcoma (bone cancer), and tumors in the brain, liver and skin.
researchers at Guelph and McMaster University have conducted tests in mice, and in cats brought to the animal Cancer Center OVC. the tests on dogs should begin next year.
in traditional treatment options, tumors grew and mice died. When researchers began injecting the virus in the spleen, tumors disappeared.
"by getting the vaccine at this unique place in the body, we were able to get an answer unprecedented immune in a minimum of time, "said Bridle.
"This is a fundamentally new way to treat cancer bypassing many common side effects. These therapies are safer and more focused."
The results have led to clinical trials for people in Ottawa, Hamilton and Toronto.
Bridle said the study could help researchers in other fields, including those seeking to treat virulent diseases such as dengue fever and Ebola.
"My research focuses on cancer, but certainly these results are applicable to other diseases. We just need to connect with people in these areas, "he said.
he is optimistic that human trials will help to improve the treatment of cancer.
" We live in a world where diseases seem to grow faster than treatment, so we need to overcome them. time is of the essence. It is a race that we must win. "
EmoticonEmoticon