Smart watch biodegradable nanoparticles promise of targeting and ablation of tumors -
Dr. Gang Zheng and a biomedical research team discovered a, biodegradable nanoparticle "smart" organic using heat and light in a controlled manner to potentially targeting and ablation of tumors with greater accuracy.
The results of proof of concept, published online today and appointed a "very important paper" in the leading journal of chemistry Angewandte Chemie , provide a viable approach to stimulate clinical utility of photothermal therapy in cancer treatment, says Dr. Zheng, senior scientist at Princess Margaret and medical biophysics professor at the University of Toronto. Dr. Zheng holds the ball president Joey and Toby Tanenbaum / Brazilian research on prostate cancer
PEARL In the laboratory, using phantom models, the nanoparticle "smart" the team dubbed -. Photothermal Auto Enhance control liposomes - showed how it can solve two bottlenecks that currently prevent a more efficient use of photothermal therapy with patients. These are overheating of the tissue that can cause collateral damage during treatment, and inability of the removal of the largest tumor volumes because the light continues to travel when it is absorbed.
Dr. Zheng, a chemist, said: "Our smart nanoparticle is cool it can absorb light, generate heat and tumor ablation is a thermal sensor and once that it reaches the desired temperature of 55C ablation, it becomes invisible allowing light to move .. deeper into several areas of the tumor and repeat the process.
"the result is a promising new way to heat and ablate larger tumor volumes with minimal damage to tissue surrounding a controlled and precise manner. The next step is to achieve pre-clinical studies to test the concept further. "
Over the last 10 years at The Princess Margaret, looking for Mr. Zheng focused on advancing the nanoparticle technology by exploiting the light, heat and sound to advance the imaging of the tumor and targeted treatment.
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