Study reveals trends for the treatment of prostate cancer in Japan -
By Joanna Lyford first medwireNews Reporter
There has been an increase recent use of Japanese radiotherapy men newly diagnosed with prostate cancer and a concomitant decrease in the use of androgen deprivation therapy (ADT), the results of the study indicate.
The trends were identified by Mizuki Onozawa (Tokyo-Kita Medical Center, Japan) and colleagues and are reported in Japanese Journal of Clinical Oncology .
For their study, the researchers examined the initial treatment of choice in 8291 men across Japan with prostate cancer. All the men were newly diagnosed biopsy disease and began treatment in 2010.
men's average age was 71 years, 40.5% had stage T1c disease and 10.4% had an M1 disease. The proportion classified as the high low, medium and using the D'Amico classification system was 19.3%, 29.8% and 25.9%, respectively. A quarter of men had locally advanced, metastatic disease, or both.
The most common initial treatment was ADT given in 40.2% of cases, followed by radical prostatectomy in 32.0%, 21.0% in the radiation (brachytherapy in 40.6% of cases ) and active surveillance in 6.4%.
for comparison, the respective values in a Japanese study in 04 were 49.8% for ADT, 31.5% for radical prostatectomy and 10.4% for radiation, indicating an increase in the use of radiation and a decrease of TDA.
"Although differences in baseline characteristics were taken into account, this trend towards increased use of radiation and a decrease in the use of ADT was further confirmed especially in localized disease "the authors write.
in the subgroup of patients with T1 disease, initial therapy was radical prostatectomy, radiation and ADT in 36.8%, 25.7% and 25.0%, respectively patients in 2010 compared to 39.0%, 13.7% and 38.4% respectively in 04.
Onozawa and co-authors say their data indicate a trend more "final / curative but conservative treatments "may be emerging in Japan. This may be driven, at least in part, by the increased use of brachytherapy and other new radiation modalities, which carry a lower charge in terms of events undesirable.
"[F] ther longitudinal studies are needed to confirm the above trend," the author notes.
Although the overall popularity of radical prostatectomy did not change significantly between 2010 and 04, there was an increase in laparoscopic procedures and a corresponding decrease in open surgery. Nevertheless, the open approach was the most widely used option in 2010, representing 77.3% of cases
The authors conclude: ". [T], it increased the proportion of radiation and the high proportion ADT independently of the stage of disease characteristics were the initial therapy for prostate cancer in Japan. "
medwireNews licensed by permission of Springer Healthcare Ltd. © Springer Healthcare Ltd. All rights reserved. None of these parties endorse or recommend any commercial products, services or equipment.
EmoticonEmoticon