FEI announces the sale of a full flow related working at the University of Maastricht -
FEI (NASDAQ: FEIC) announces the sale of a correlative workflow complete at the University of Maastricht. The systems will be installed at the Institute of the University of nanoscopy, a new research facility which will use high-resolution microscopes to understand protein complexes working mechanisms in an effort to develop new and improved treatment and prevention of the disease, such as cancer and tuberculosis.
"Our ultimate goal is to biological nanomachines images and their mode of action at the macromolecular level, pushing the current limits of the visual proteomics and nanotechnology," said Peter Peters, university professor nanobiologie of the Faculty of Health, medicine and life sciences, and head of the Institute of nanoscopy. "Cryo-electron microscopy is the only way to study cellular processes close to the situation in vivo. To do this, a complete workflow is necessary for live cell imaging with fluorescent markers by cryo-fixation for preserve the structure, and finally, using high-resolution cryo-electron tomography to visualize three-dimensional structures to the nanoscale. FEI is the only company that can provide this complete workflow from beginning to end . "
the full workflow delivered at the University of Maastricht begins with live cell imaging using CorrSight ™, an advanced optical microscope that is designed specifically for use in correlative experiences and allows researchers to the dynamic image living cells and, when targeted event is observed, quickly correct these cells for electron microscopy (EM). MAPS ™ EIF software tracks the position and the target coordinates and provides a common operating interface between different tools across the entire workflow. The sample, as well as contact information, is then transferred to Scios DualBeam ™ (/ focused beam of ions to the scanning electron microscope) of the system, which attenuates the areas of interest identified until the appropriate thickness of 100 to 0 nm while maintaining cryogenic conditions. The sample is transferred to the thinned transmission electron microscope Arctica Tecnai ™ (MET) for high-resolution imaging and analysis. The Arctica is especially designed for automated, high-throughput cryo-tomography, which acquires a sequence of images from different points of view to reconstruct a 3D model of the target.
According to Peter Fruhstorfer, FEI's vice president and general manager of life sciences, "The complete workflow provides a seamless way to study cells and biological processes. It reduces the tedious manual labor and improves the reproducibility of the data. "He added:" We have a longstanding relationship with Dr. Peters, who is a well known leader and researcher in his field. We look forward to working with him to expand the use of cryo-EM in medical research. "
The research team at the Institute of the University of nanoscopy will emphasize the revelation of the 3D structure of a large complex called 'type VII secretion system" present in the wall cell Mycobacterium tuberculosis and the most important virulence factor. This knowledge can help improve the vaccine currently used against tuberculosis (TB). This research is based on the findings of Dr. Peters on how the bacteria that cause tuberculosis behave in cells, which was published in cell in 07. the Institute also aims to develop a better understanding of the immune system, which can potentially lead to an immune response against cancer cells the human body. in addition, the team will continue to work on improving sample preparation for cryo-EM.
please visit for more www.maastrichtuniversity.nl/nanoscopy information. For more information on correlative workflow EIF, please visit: http://www.fei.com/life-sciences/cellular-biology/.
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