A study highlights a potential new treatment for heatstroke -
The Taiwan scientists have found that intravenous injections of stem cells derived from the pulp of deciduous exfoliated human teeth (SHED) have a protective effect against brain damage from heat stroke in mice. Their conclusion was safe and effective and may be a candidate to successfully treat human patients by preventing neurological damage caused by heat stroke.
The study is published in an upcoming issue of Cell Transplantation and is currently available for free online as an e-pub unpublished beginning to http: //www.ingentaconnect. com / content / cog / ct / pre-prints / content-CT1100Tseng.
"death heat stroke is increasing worldwide and brain damage induced by stroke heat is the third cause of death after cardiovascular disease and traumatic brain injury, "said study lead author Dr. Ying-Chu Lin Kaohsiung medical University school of dental medicine, Kaohsiung city, Taiwan. "Heat stroke is characterized by hyperthermia, systemic inflammatory response, multiple organ failure and brain dysfunction."
To study the beneficial therapeutic effects and potential offered by the activities of protection of self-renewing stem cells derived from human exfoliated deciduous teeth, the scientists transplanted into mice that had undergone heat stroke experimental HANGAR.
According to the research team, these cells have "significantly higher proliferation rate" that stem cells from bone marrow and have the added advantage of being easy to harvest and express more growth factors including vascular endothelial growth factor (VEGF), and they can promote the migration and differentiation of neural progenitor cells (NPCs).
"We have observed that intravenous administration of HANGAR publish immediately -Heat stroke had several therapeutic benefits," said Dr. Lin. "These included the inhibition of neurological deficits and reduced oxidative damage to the brain. We believe that the protective effect of SHED may be related to a reduced inflammatory response, decreased oxidative stress and increased hypothalamic-pituitary -surrénale activity of the axis following the heat stroke of injury. "
There are currently some disadvantages to the experimental therapy, the researchers said. First, there is a limited amount SHED. Also, HANGAR transplantation was associated with cancer and immune rejection.
"Further studies are needed to determine the mechanism or the production of growth factors in our SHED mediated specific heat stroke model," concluded the researchers.
"This study provides the first step toward a potential therapy for the treatment of heat stroke, "said Dr. Shinn-Zong Lin, professor of neurosurgery and director of the university hospital of China medical, Beigang, Taiwan and co-editor-in-chief of cell transplantation . "the use of HANGAR is an interesting approach that requires further study to elucidate the cellular and secretory factors necessary to benefit."
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