Friday, August 16, 2013

Researchers identify gene loci six associated with pulmonary diseases

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Researchers identify gene loci six associated with pulmonary diseases -

In their investigations or so-called genome-wide association studies, the research team compared the genetic profile participants in the study of forced vital capacity (FVC), a volume parameter of lung function. Six loci genes here displayed a clear association with FVC values. The involvement in the development of lung or certain lung diseases is also suspected of these genes.

A better understanding of the association between genes, lung function and lung disease

The identified genes open new approaches to molecular biology for better understanding of lung development and repair and remodeling processes in the pathogenesis of the disease. "The results provide the basis for detailed research on lung disease and clarify the association between genetics, lung function and susceptibility to respiratory disorders," reports Prof. Dr. Holger Schulz, head of the research group pulmonary Epidemiology at Helmholtz Zentrum M nchen (HMGU). "in the context of these results, we can, for example identify possible risk groups and to develop new therapeutic approaches," adds Dr. Christian Gieger (HMGU)

analysis of the complete genome :. More than 85,000 participants from 35 studies

Under the direction of the National Institute of Health Sciences of the environment in the United States, the team of international scientists analyzed data on a total of 85.170 participants from 35 cohorts. There were also participants in the German KORA cohort studies, which were evaluated by scientists HMGU. The Institute of Epidemiology I and II (EPI I, II EPI), the Institute of Genetic Epidemiology (IGE) and the full Pneumology Center (CPC) in HMGU were involved.


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