Losing weight can reduce the levels of certain proteins linked to tumor growth -
Bottom Line: Women in overweight and obese people who lost weight by diet and exercise reduced levels of certain proteins in their blood that play a role in angiogenesis, the process of growth of blood vessels that can promote the growth and survival of cancer cells
Log in which the study was published :. Cancer Research , a journal of the American Association for Cancer Research
Author :. Catherine Duggan, Ph.D., Scientific Director of the staff of the Public Health Sciences Division at the Research Centre for Cancer Fred Hutchinson in Seattle, Washington
Background: Angiogenesis is a vital function when new blood vessels are formed, for example, during wound healing, Duggan explained. Unfortunately, a significant portion of tumor growth and development is dependent on a supply of blood vessels to provide nutrients and oxygen to allow a tumor to continue to grow. Some researchers have proposed that "angioprevention," that is, preventing the growth of tumor cells by preventing angiogenesis, may be an important strategy for preventing cancer in healthy people, but drugs that block this processes have potential adverse effects, which is a deterrent to use for cancer prevention, she said
How the study was done :. Duggan, senior study author Anne McTiernan, MD, Ph.D., and colleagues randomly assigned 439 obese, healthy, postmenopausal women overweight / sedentary, aged 50 to 75, to one the four arms of the study to measure the effect of exercise and diet on circulating levels of proteins associated with angiogenesis after 12 months
four arms were :. a calorie restriction diet arm in which women restricted their caloric intake to no more than 00 kcal per day which included less than 30 percent of calories from fat; an aerobic exercise arm in which women performed 45 minutes of moderate to vigorous exercise five days a week; diet + exercise combined arms; and a control arm (no response)
Blood samples were collected at the beginning and 12 months
Results: .. After adjusting the data for the index body mass, age, and race / ethnicity, the researchers found that after 12 months of intervention, on average, women in the food arm, the arm of exercise and diet + exercise arm lost 8.5, 2.4 and 10.8, percent of body weight, respectively, which was significantly higher than the average weight loss for women in the control arm (0.8 percent).
After 12 months, compared to women in the control arm, those in power arm and diet + exercise arm had significantly lower levels of proteins associated with angiogenesis, but these effects are not obvious to those of the drive arm only. The researchers also observed a linear trend in the reductions, which means that weight loss had more women, more reductions in their levels of protein related to blood angiogenesis.
The proteins studied include VEGF, PAI-1. and PEDF
Author Comment: ". We know that being overweight and having a sedentary lifestyle is associated with an increased risk of developing certain types of cancer, however, we do not know exactly why" Duggan said. "We wanted to investigate how the levels of certain biomarkers associated angiogenesis have been changed when overweight, sedentary, postmenopausal women participating in a research study lost weight and / or become physically active during a year. "
" Our study shows that weight loss is a safe and effective method to enhance the angiogenic profile in healthy individuals. We were surprised by the magnitude of change in these biomarkers with weight loss, "said Duggan.
"While we can 't say for certain that the reduction of circulating levels of angiogenic factors by the weight loss would affect tumor growth, it is possible they could be associated with a environment less conducive to tumor growth and proliferation, "noted Duggan.
"exercise is important to help prevent weight gain and maintain weight loss, but does not cause a large amount of weight loss on its own" Duggan said. "Our study shows that lifestyle changes - in this case, simple changes to diet to reduce weight. - can reduce risk factors for cancer "
Limitations: The researchers measured three angiogenic factors while there are many others. In addition, biomarkers were measured only in the circulating blood and not in the adipose tissue or other tissue, said Duggan.
Log in which the study was published :. Cancer Research , a journal of the American Association for Cancer Research
Author :. Catherine Duggan, Ph.D., Scientific Director of the staff of the Public Health Sciences Division at the Research Centre for Cancer Fred Hutchinson in Seattle, Washington
Background: Angiogenesis is a vital function when new blood vessels are formed, for example, during wound healing, Duggan explained. Unfortunately, a significant portion of tumor growth and development is dependent on a supply of blood vessels to provide nutrients and oxygen to allow a tumor to continue to grow. Some researchers have proposed that "angioprevention," that is, preventing the growth of tumor cells by preventing angiogenesis, may be an important strategy for preventing cancer in healthy people, but drugs that block this processes have potential adverse effects, which is a deterrent to use for cancer prevention, she said
How the study was done :. Duggan, senior study author Anne McTiernan, MD, Ph.D., and colleagues randomly assigned 439 obese, healthy, postmenopausal women overweight / sedentary, aged 50 to 75, to one the four arms of the study to measure the effect of exercise and diet on circulating levels of proteins associated with angiogenesis after 12 months
four arms were :. a calorie restriction diet arm in which women restricted their caloric intake to no more than 00 kcal per day which included less than 30 percent of calories from fat; an aerobic exercise arm in which women performed 45 minutes of moderate to vigorous exercise five days a week; diet + exercise combined arms; and a control arm (no response)
Blood samples were collected at the beginning and 12 months
Results: .. After adjusting the data for the index body mass, age, and race / ethnicity, the researchers found that after 12 months of intervention, on average, women in the food arm, the arm of exercise and diet + exercise arm lost 8.5, 2.4 and 10.8, percent of body weight, respectively, which was significantly higher than the average weight loss for women in the control arm (0.8 percent).
After 12 months, compared to women in the control arm, those in power arm and diet + exercise arm had significantly lower levels of proteins associated with angiogenesis, but these effects are not obvious to those of the drive arm only. The researchers also observed a linear trend in the reductions, which means that weight loss had more women, more reductions in their levels of protein related to blood angiogenesis.
The proteins studied include VEGF, PAI-1. and PEDF
Author Comment: ". We know that being overweight and having a sedentary lifestyle is associated with an increased risk of developing certain types of cancer, however, we do not know exactly why" Duggan said. "We wanted to investigate how the levels of certain biomarkers associated angiogenesis have been changed when overweight, sedentary, postmenopausal women participating in a research study lost weight and / or become physically active during a year. "
" Our study shows that weight loss is a safe and effective method to enhance the angiogenic profile in healthy individuals. We were surprised by the magnitude of change in these biomarkers with weight loss, "said Duggan.
"While we can 't say for certain that the reduction of circulating levels of angiogenic factors by the weight loss would affect tumor growth, it is possible they could be associated with a environment less conducive to tumor growth and proliferation, "noted Duggan.
"exercise is important to help prevent weight gain and maintain weight loss, but does not cause a large amount of weight loss on its own" Duggan said. "Our study shows that lifestyle changes - in this case, simple changes to diet to reduce weight. - can reduce risk factors for cancer "
Limitations: The researchers measured three angiogenic factors while there are many others. In addition, biomarkers were measured only in the circulating blood and not in the adipose tissue or other tissue, said Duggan.
EmoticonEmoticon